Rapid detection of the two most common CLN2 mutations causing classical late infantile neuronal ceroid lipofuscinosis.

LBM should be taken into account (1 ). However, as shown here and previously (3 ), the contribution of LBM to variations in serum creatinine is small. The group of subjects studied were all females, and this may account for the low contribution. However, their LBM covered a wide range (23.0–53.7 kg), and thus it is likely that the findings here would be widely applicable. These results suggest that although creatinine production increases with increasing LBM, there is a concomitant increase in the volume of distribution of creatinine, thereby reducing the relationship between serum creatinine and LBM. Total body water is related to LBM, and Shutte et al. (9 ) have shown that LBM and total plasma creatinine (plasma volume 3 creatinine concentration) are well correlated. We conclude that the contribution of LBM to serum creatinine is small and that correction of serum creatinine according to LBM is unlikely to improve the usefulness of this measurement.